African signatures of recent positive selection in human FOXI1

Table 4 Core haplotypes with significant REHH values in Africans involving FOXI1

H^a	REHH	Frequency	Distance (bp)^b	Distance (cM)^c	Core haplotype	Genes in core regionⁱ	Pvalue	qvalue^j
0.02	19.58	0.528	80443	0.056	ACCC^d	DOCK2, FOXI1	0.8 × 10^-5	0.0038
0.04	16.93	0.528	61086	0.026	ACCC^d	DOCK2, FOXI1	0.3 × 10^-5	0.0016
0.04	12.08	0.590	-64129	-0.058	AGC^e	FOXI1	0.6 × 10^-4	0.0213
0.04	8.32	0.675	-41241	-0.051	AG^f	DOCK2, FOXI1	0.8 × 10^-4	0.0247
0.04	10.42	0.528	55531	0.028	A^g	DOCK2, FOXI1	0.8 × 10^-4	0.0191
0.04	10.65	0.561	-54967	-0.053	CTG^h	DOCK2, FOXI1	1.2 × 10^-4	0.0215

^aDegree to which each added marker at a further distance causes the extended haplotypes to decay for all core haplotypes
^bPhysical distance (bp) from the core at which the signal has been captured. (-) indicates downstream direction. Otherwise upstream
^cGenetic distance (cM) from the core at which the signal has been captured. (-) indicates downstream direction. Otherwise upstream
^drs7736379, rs6872596, rs4449553, rs17562083
^ers7729440, rs2879278, rs11134616
^frs4867919, rs11134612
^grs1501644
^hrs7709558, rs12515896, rs6861611
ⁱGenes within ±100 kb around the core are considered
^jExpected proportion of false positives among all significant p values

ISSN: 2730-7182