Table 3 Panther over-represented categories among genes showing correlation with helminth diversity

Pathway

Integrin signalling pathway

26

0.0067

ITGAV, COL4A1, ITGA8, FLNB, ITGA9, ITGB8, ITGAM, ITGBL1, COL4A2, COL1A2, DOCK2, PTK2B, ITGAX, FYN, MAPK13, LAMA2, ITGAL, LIMS1, COL24A1, ELMO1, COL15A1, DOCK1, GRB2, ITGB7, MAPK14, COL9A3

Alpha adrenergic receptor signaling pathway

8

0.0138

PLCB1, ADRA1A, ITPR1, GNAQ, SNAP25, PLCE1, VAMP3, ITPR2

Inflammation mediated by chemokine and cytokine signaling pathway

31

0.0206

SOCS6, PLCH2, PLCB1, GRB2, GNG10, ITPR1, CXCR6, MYH14, ITGA9, MYO3B, PLA2G4B, GNAQ, CAMK2A, PLCL1, CAMK2 D, ITGAM, CCR9, COL1A2, ITGB7, PAK7, VAV2, PLCD3, ADCY2, PTK2B, PLCE1, RELA, ITPR2, CCL20, PLA2G4A, ITGAL, COL23A1

Ionotropic glutamate receptor pathway

11

0.0263

SLC17A8, GRIK2, GRIA1, CACNG5, GRIN3A, SHANK2, CAMK2A, SNAP25, CAMK2 D, VAMP3, CACNG8

Thyrotropin-releasing hormone receptor signaling pathway

11

0.0303

PLCH2, PLCB1, CGA, CACNB2, GNG10, GNAQ, PLCD3, CHGA, PLCE1, VAMP3, SNAP25

Biological

process

Signal transduction

270

4.05 × 10^-17

n.r.

Cell adhesion

73

7.18 × 10^-11

n.r.

Cell communication

113

9.11 × 10^-10

n.r.

Cell structure and motility

103

1.35 × 10^-8

n.r.

Neuronal activities

63

2.25 × 10^-8

n.r.

Developmental processes

163

2.87 × 10^-8

n.r.

Ion transport

64

8.48 × 10^-7

n.r.

Cation transport

54

1.61 × 10^-6

n.r.

Molecular

function

Ion channel

44

4.06 × 10^-7

n.r.

Receptor

117

2.79 × 10^-6

n.r.

Hydrolase

66

1.92 × 10^-5

n.r.

G-protein modulator

45

2.84 × 10^-5

n.r.

Cell adhesion molecule

42

3.92 × 10^-5

n.r.

Signaling molecule

68

6.44 × 10^-5

n.r.

Membrane-bound signaling molecule

20

8.95 × 10^-4

n.r.