Figure 7From: Phylogenomics reveals subfamilies of fungal nonribosomal peptide synthetases and their evolutionary relationshipsPhylogenetic analysis of the Euascomycete subclade. Tree extracted from the maximum likelihood (PhyML with WAG plus gamma substitution matrix) phylogeny of the complete A domain dataset (Additional file 6B). Branches defining subgroups of the EAS clade grouping with a C. heterostrophus NRPS A domain or with A domains from fungal NRPSs with known function are color coded: dark blue = peptaibol synthetases, light blue = ChNPS4 (clades grouping with each A domain of C. heterostrophus NPS4), green = AMT synthetases and ChNPS1 and ChNPS3 modules 1 and 3, orange = ergot alkaloid synthetases, light green = ChNPS8/PerA synthetases, and red = homologs of ChNPS6 (extracellular siderophore synthetases). Of these groups, only the peptaibol synthetases, the clade containing NPS8/PerA/NPS6 synthetases (arrow), and ChNPS4 modules 3 and 4 have bootstrap support >70%. C. heterostrophus NRPS A domains are indicated (circles).Back to article page