Figure 5

Strong negative correlations between EBs and evolutionary rates are maintained when EAs are fixed. Data with a similar range of EAs were grouped together, resulting in 10 different groups. The genes in each group have similar EAs but different ranges of EBs and evolutionary rates. The boxes with nested numbers in the upper right corner (grey) are the groups, and the numbers in the boxes correspond to those in Table S1A of Additional file 2. The lines in each group are derived from linear regression analysis results. All the groups consistently show that the negative correlations between EBs and evolutionary rates are maintained when the EAs are fixed as evenly as possible.