Figure 1

Maximum likelihood tree of ferlin genes from selected phyla. The putative ferlin from Pfal was used as an outgroup (CAX64098). Bootstrap values from 100 iterations are shown for major branches. Bootstrap values below 55 are indicated by an asterisk. DysF containing ferlins are partitioned into the bottom half of the tree (shaded blue box), while the non-DysF containing ferlins are partitioned into the top half of the tree (shaded orange box). FER1 and FERL1 of C. elegans form a separate sub-tree within the DysF subtree, while Misfire of D. melanogaster form an outgroup in the non-DysF subtree.