Skip to main content

Table 1 Summary Statistics of PAML analyses

From: Diversifying selection and functional analysis of interleukin-4 suggests antagonism-driven evolution at receptor-binding interfaces

NSsites Model comparison

2 lnλ (df)

p-value

%codons dN/dS >1

average dN/dS

M7 vs M8, eutherian mammals- 28 taxa (including elephant, carnivores, rabbit, rodents, primates)

20.84 (2)

<10 -4

15.2

1.87

M7 vs M8, eutherian mammals excluding Lagomorphs & Rodentia (21 mammals)

20.61 (2)

<10 -4

16.7

2.14

M7 vs M8, Lagomorphs & Rodentia alone (7 taxa)*

19.56 (2)

<10 -4

5.6

6.34

M7 vs M8, primates alone (16 taxa incl. 2 prosimians)

0.737 (2)

>0.5

na

na

M7 vs M8, eutherian mammals excluding primates (23 taxa)

17.28 (2)

<0.0002

18.5

1.75

M7 vs M8, Laurasiatheria alone (15 taxa)

13.15 (2)

<0.002

16.3

2.02

  1. All analyses were done using the Fcodon model. Results are qualitatively identical using the F3 × 4 model of codon substitution.
  2. lnλ = log likelihood difference between the two models
  3. df = degrees of freedom
  4. *Multiple topologies for rodent phylogenies were tested due to poor phylogenetic resolution in this lineage - the conclusion of positive selection is not dependent on the use of a particular topology; the values reported are those found when used with a phylogeny consistent with the consensus view of rodent evolution.