Molecular basis of a novel adaptation to hypoxic-hypercapnia in a strictly fossorial mole

Table 2 Respiratory characteristics of eastern, coast and star-nosed mole whole blood

	36°C				36°C				ΔlogP_50/ΔpH⁴	32°C		40°C		ΔH⁵(kJ mol^-1O₂)	Δlog P₅₀/ΔT
	PCO₂= 38 mm Hg				PCO₂= 38 mm Hg					PCO₂= 38 mm Hg		PCO₂= 38 mm Hg
	pH	P₅₀¹	P_d²	n ₅₀ ³	pH	P₅₀	P_d	n ₅₀		P₅₀	n ₅₀	P₅₀	n ₅₀
Eastern mole	7.36	28.8	21.9	2.76	7.76	14.1	10.1	2.54	-0.78	25.3	2.78	31.0	2.71	-8.3	0.011
Coast mole	7.58	17.7	13.6	2.84	8.48	6.1	4.2	2.44	-0.52	16.9	2.85	19.3	2.82	-1.0	0.008
Star-nosed mole	7.56	22.5	17.1	2.76	8.61	8.0	6.0	2.86	-0.40	17.3	2.95	26.6	2.90	-29.9	0.023

¹P₅₀ (mm Hg) = PO₂ corresponding to 50% oxygen saturation
²P_d (mm Hg) = P50 × ((n₅₀-1)/(n₅₀+1))^1/n50; represents arterial PO₂ at which oxygen offloading is maximal [41]
³n₅₀ = Hill coefficient; slope of log (%oxyHb/%deoxyHb) versus log PO₂
⁴CO₂-Bohr effect; pH varies by CO₂ titration
⁵Overall heat of oxygenation.

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