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Table 2 Placement of Myotubularin Homologue Sequences into Phylogenetic Similarity Clusters

From: A phylogenetic survey of myotubularin genes of eukaryotes: distribution, protein structure, evolution, and gene expression

"M1"(+)

"R3"(+)

"R5"(-)

"R6"(+)

"R9"(-)

"R10"(-)

0.998 ± 0.0005

0.998 ± 0.0005

0.958 ± 0.032

1.000 ± 0.000

0.990 ± 0.014

0.913 ± 0.118

84.8 ± 10.5

91.5 ± 15.0

87.5 ± 8.2

98.5 ± 1.3

95.3 ± 2.5

89.0 ± 19.4

MTM1_Hu

MTMR3_Hu

MTMR5_Hu

MTMR6_Hu

MTMR9_Hu

MTMR10_Hu

MTMR1_Hu

MTMR4_Hu

DrMTMR5

MTMR7_Hu

DrMTMR9

DrMTMR10

MTMR2_Hu

N001631983

MTMR13_Hu

DrMTMR7

N001625874

MTMR11_Hu

DrMTMR2

Tad64213

Nv109357

MTMR8_Hu

Tad28926

MTMR12_Hu

N001636543

 

Tad51481

N001626810

M01749550C

N001629628

Tad38469

 

M001750622

Tad56124

 

Tad54716

   

M01746603C

  
  1. Myotubularin homologue sequences from human ("Hu") and Danio rerio ("Dr") were obtained from the literature and database keyword searches. For the other species represented, candidate myotubularin sequences were obtained by searching the protein datasets of fully sequenced eukaryotic genomes, as detailed in Methods. The prefix "N" or "Nv" followed by a numeral denotes sequences from Nematostella vectensis, "Tad" followed by a numeral denotes sequences from Trichoplax adhaerens, and "M" followed by a numeral denotes sequences from Monosiga brevicollis, (except "Mbrevi5R3" which is also from Monosiga). The sequences were aligned as detailed in Methods. Phylogenetic trees were inferred as detailed in Methods. Shown are the composition and clade support for the six similarity groups previously identified [2, 3]. The plus and minus symbols (+,-) indicate the presence of enzymatically active or inactive catalytic loop sequence signatures, respectively. For each group, the number above the line indicates the Bayesian clade support (posterior probability), and the number below the line indicates the bootstrap support (out of 100 total replicates) in Maximum Likelihood (ML). Results presented are the mean (± SD) of four distinct alignments.
  2. Sequences Tad51955 and M01745983 consistently clustered together as a distinct "new clade". The mean Bayesian posterior probability was: 0.998 (± 0.0005) (n = 4). The mean bootstrap support in Maximum Likelihood (ML) was: 97.5 (± 0.577) (n = 4).
  3. Sequences Nv82921, Tad62282 and MBrevi5R3 could not be placed into a similarity group with confidence.
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BMC Ecology and Evolution

ISSN: 2730-7182

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