Summary of Domain Distribution in Eukaryotic Myotubularin Homologues. Myotubularin homologues were identified by HMM searches of protein datasets from completely sequenced eukaryotic genomes and domains were mapped as detailed in Methods. Colour code: In black, domain present; In white, domain absent; In gray, inactive myotubularin in Entamoeba histolytica plus PH-GRAM domain, relationship to similar proteins in Choanoflagellates and Metazoa indeterminate. IMLRK (inactive myotubularin/LRR/ROCO/Kinase proteins) of Amoebozoa also contain a PH-GRAM domain. Species are identified by a three letter abbreviation (Genus species [e.g. Gsp]). Species are as in Figure 1. Taxonomic descriptions and color coding are as in Figure 1. "Apicom" = Apicomplexa; "Archam" = Archamoebae"; "Bryophyt" = Bryophyta; "Choano" = Choanoflagellida; "Dictyo" = Dictyostelida; "Diplomon" = Diplomonadida; "Stramen" = Stramenopiles. Figure design after Gazave et al., 2009 .