Positive selection of HIV host factors and the evolution of lentivirus genes

Table 2 Interaction specificities of HIV-related host factors in the interaction grouping.

		proteins	local connectivity	centrality	pathogens	pathogen groups
	PR	27	<0.01 (+)	<0.01 (+)	-	-
Pol-encoded	RT	20	0.01 (+)	<0.01 (+)	-	-
	IN	49	<0.01 (+)	-	-	<0.01 (+)
	Nef	97	-	0.03 (+)	-	-
	Rev	42	<0.01 (+)	0.01 (+)	<0.01 (+)	<0.01 (+)
	Tat	455	-	-	-	0.01 (-)
	Vif	45	<0.01 (+)	-	-	<0.01 (+)
	Vpr	98	<0.01 (+)	0.03 (+)	0.03 (+)	0.01 (+)
	Vpu	20	-	<0.01 (+)	0.02 (+)	0.01 (+)
	MA	54	-	-	-	<0.01 (+)
	CA	18	0.03 (-)	-	-	-
Gag-encoded
	NC	16	-	-	<0.01 (+)	-
	p6	8	0.01 (+)	<0.01 (+)	<0.01 (+)	<0.01 (+)
	Gag	26	0.01 (-)	-	0.01 (-)	<0.01 (+)
	gp120	175	-	-	-	-
	gp41	61	<0.01 (-)	-	0.01 (-)	<0.01 (-)
Env-encoded
	Env	57	0.04 (-)	-	-	-

P-values of the significance of local connectivity, centrality, number of interacting pathogens and pathogen groups are indicated with a (+) sign for high values and a (-) sign for low values.

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