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Table 1 Ranking of viral proteins based on the relative evolutionary rate and characterization of interacting host genes.

From: Positive selection of HIV host factors and the evolution of lentivirus genes

 

rank

relative evol. rate

interacting genes

% genes under positive selection

mean norm. site-based rank

mean norm. sliding window rank

gp120

1

4.36

434

12.9

0.452

0.481(+)

Vpu

2

3.82

22

18.2

0.292

0.520

Env

3

3.06

145

15.9

0.448

0.497(+)

p6

4

2.43

12

16.7

0.258

0.681

Rev

5

2.21

59

6.8

0.737(-)

0.757(-)

gp41

6

2.07

123

16.3

0.427

0.488(+)

Nef

7

2.02

168

12.5

0.432

0.526

Gag

8

1.87

45

13.3

0.105(+)

0.615

Vif

9

1.77

55

16.4

0.350

0.659(-)

Tat

10

1.77

636

11.0

0.522

0.606

MA

11

1.70

69

7.2

0.542

0.742(-)

NC

12

1.60

19

15.8

0.416

0.759(-)

Vpr

13

1.58

152

11.2

0.647(-)

0.614

RT

14

1.42

33

9.1

0.606

0.621

Pol

15

1.38

1

100.0

0.190

0.094

CA

16

1.37

21

28.6

0.235

0.373(+)

PR

17

1.30

71

21.1

0.709(-)

0.629(-)

IN

18

1.00

66

7.6

0.729(-)

0.727(-)

  1. Positively selected host genes are inferred from the significance of the LRT. Signs in parentheses indicate significantly high (+) and low (-) mean normalized rank of interacting host genes under positive selection. Ranks in both scorings are normalized to [0,1] range to facilitate comparison.