Figure 4

Greater conservation of DNA sequences between human ARGFX , OTX1 and OTX2 genomic regions than with DPRX and TPRX1. Human GSC and HESX1 were also used as references, but no similarity was found. Genomic sequences from the last base pair of upstream gene to the first base pair of downstream gene for each locus (based on UCSC at http://genome.ucsc.edu/ were used, and compared using Shuffle-LAGAN [28] in mVISTA, which can detect sequence rearrangements. Coloured peaks (purple, coding; pink, intergenic; blue, transcribed non-coding) indicate regions of at least 30 bp and 30% similarity.