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Table 4 Over- and under-represented (italics) GO terms when duplicated genes are compared against singleton genes.

From: Duplicability of self-interacting human genes

Biological processes
GO IDs Term Obs. Mean S. D. Z score p-valuea
GO:0007154 cell communication 2009 1819.3 17.5 10.8 5.86E-27
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1446 1630.6 16.6 -11.1 4.08E-25
GO:0009058 biosynthetic process 1522 1650.6 17.0 -7.6 2.21E-12
GO:0050789 regulation of biological process 3130 3001.9 18.3 7.0 5.91E-11
GO:0007275 multicellular organismal development 1346 1241.1 15.8 6.7 1.76E-10
GO:0032501 multicellular organismal process 787 712.5 12.4 6.0 2.34E-08
GO:0022904 respiratory electron transport chain 3 14.9 1.9 -6.2 1.45E-06
GO:0043170 macromolecule metabolic process 2628 2726.8 18.2 -5.4 1.72E-06
GO:0030154 cell differentiation 726 673.2 12.1 4.4 3.02E-04
GO:0007610 behavior 218 189.6 7.1 4.0 3.39E-04
GO:0006928 cell motion 300 267.4 8.3 3.9 6.67E-04
GO:0009056 catabolic process 452 487.6 11.0 -3.2 1.70E-02
GO:0005634 nucleus 1 5.1 1.2 -3.4 4.85E-02
GO:0016787 hydrolase activity 1 5.1 1.2 -3.4 4.85E-02
Molecular Function
GO IDs Term Obs. Mean S. D. Z score p -value a
GO:0005488 binding 2905 2686.899 18.3 11.9 3.85E-29
GO:0004872 receptor activity 714 608.911 12.3 8.6 2.06E-19
GO:0016301 kinase activity 496 420.462 10.0 7.5 4.99E-14
GO:0015267 channel activity 203 159.644 6.6 6.6 1.28E-12
GO:0015075 ion transmembrane transporter activity 300 247.312 8.1 6.5 2.48E-11
GO:0004871 signal transducer activity 315 265.132 8.2 6.1 2.76E-09
GO:0003676 nucleic acid binding 1211 1290.829 16.5 -4.8 3.31E-05
GO:0016787 hydrolase activity 870 813.748 13.8 4.1 7.61E-04
GO:0045182 translation regulator activity 36 51.717 3.6 -4.3 2.28E-03
GO:0003774 motor activity 68 55.557 3.7 3.4 1.09E-02
GO:0016874 ligase activity 138 161.46 6.4 -3.7 1.21E-02
  1. a The estimated P values were adjusted by Bonferroni correction.