Evidence of positive selection at codon sites localized in extracellular domains of mammalian CC motif chemokine receptor proteins

Table 2 Positively Selected Sites Under Different PAML Site Models Using Bayes Empirical Bayes Analysis.

Gene	Model	Codon	Domain	Amino Acid	Posterior Probability	Post Mean +- SE for ω
CCR2	M8: Selection, beta+ ω	16	EC	S	0.632	1.536 +- 0.783
		23	EC	F	0.795	1.796 +- 0.781
		43	EC	Q	0.0916	1.977 +- 0.729
		95	MB	L	0.795	1.807 +- 0.810
		115	EC	L	0.623	1.535 +- 0.825
		183	EC	K	0.0926	1.986 +- 0.720
		187	EC	V	0.705	1.678 +- 0.831
		196	EC	R	0.961*	2.028 +- 0.691
		197	EC	G	0.862	1.910 +- 0.771
CCR3	M2a: Selection	4	EC	S	0.638	3.459 +- 2.147
		5	EC	L	0.988*	4.851 +- 1.496
		20	EC	V	0.998**	4.881 +- 1.453
		179	EC	T	0.919	4.581+- 1.731
		181	EC	T	0.878	4.378 +- 1.807
CCR3	M8: Selection, beta+ ω	4	EC	S	0.824	2.296 +- 0.904
		5	EC	L	0.988*	2.590 +- 0.683
		20	EC	V	0.997**	2.603 +- 0.667
		31	EC	A	0.549	1.734 +- 0.921
		95	EC	R	0.681	2.000 +- 0.947
		96	EC	G	0.598	1.830 +- 0.940
		104	EC	G	0.863	2.347 +- 0.833
		177	EC	L	0.528	1.688 +- 0.902
		179	EC	E	0.550	1.748 +- 0.967
		181	EC	T	0.962*	2.545 +- 0.729

Asterisks indicate posterior probability P > 95% (*) and P > 99%(**). For codon position, the amino acid number is given followed by an abbreviation for the domain in which the amino acid is found: EC = extracellular, MB = membrane bound, IC = intracellular.

ISSN: 2730-7182