Figure 1

Motif architecture of LSF and GRH proteins from 10 metazoan taxa, a choanoflagellate, and two fungi. Conserved motifs were identified using MEME, as described in the methods. Motifs (colored boxes) and inter-motif regions (thick black lines) were drawn to scale except for certain lengthy inter-motif regions, which were truncated by 50% (0.5×). Thin colored lines highlight motif conservation between proteins. The relative relationships among taxa depicted here reflect a general consensus among molecular phylogenetic analyses [62–68], although there continues to be controversy surrounding key elements of the phylogeny including the placement of ctenophores [69] and the monophyly of the triploblasts [70–72].