High correlation between the turnover of nucleotides under mutational pressure and the DNA composition

Table 1 Tables of substitutions, DNA composition in the equilibrium with the mutational pressure and half times of nucleotide substitutions.

Substitution	BbTS real	BbTS artificial	pseud 1	pseud 2	pseud m	pseud h	mtdros 4d	mtdros 3p	mtDNA l, 2p
A>T	0,103	0,222	0,047	0,024	0,017	0,087	0,124	0,019	0,069
A>G	0,067	0,111	0,050	0,138	0,068	0,149	0,013	0,148	0,082
A>C	0,023	0,016	0,094	0,031	0,068	0,000	0,029	0,005	0,094
T>A	0,066	0,189	0,044	0,024	0,057	0,025	0,004	0,021	0,054
T>G	0,035	0,002	0,082	0,030	0,114	0,013	0,075	0,005	0,016
T>C	0,035	0,002	0,033	0,126	0,095	0,025	0,379	0,086	0,182
G>A	0,164	0,023	0,210	0,214	0,166	0,177	0,056	0,449	0,118
G>T	0,116	0,178	0,072	0,047	0,030	0,076	0,000	0,041	0,030
G>C	0,015	0,056	0,053	0,051	0,060	0,050	0,000	0,000	0,031
C>A	0,070	0,186	0,065	0,052	0,076	0,052	0,288	0,000	0,087
C>T	0,261	0,010	0,210	0,211	0,172	0,312	0,000	0,227	0,216
C>G	0,047	0,004	0,042	0,054	0,076	0,035	0,124	0,000	0,020
DNA composition
A	30,8	30,8	31,3	30,8	41,0	17,0	27,4	29,8	24,7
T	48,5	48,5	37,2	30,8	17,1	65,6	50,1	43,6	31,5
G	13,8	13,8	15,8	19,9	23,9	11,7	8,3	9,4	17,2
C	6,9	6,9	15,8	18,5	18,1	5,6	14,3	17,2	26,6
Half time of substitution
τ_A	361	199	364	360	450	294	412	404	283
τ_T	513	359	437	385	262	1103	637	622	274
τ_G	236	269	207	223	270	229	159	141	388
τ_C	183	346	219	219	214	174	240	306	214
Correlation coeff.	0,999	0,072	0,998	0,991	0,967	0,998	0,997	0,988	-0,764

Explanations: BbTS real – the table of substitutions in the B. burgdorferi genome on the leading strand estimated as described in the Method section; BbTS artificial – one of the possible tables which produce the DNA asymmetry and composition like BbTS real; pseud 1 – data for mammal pseudogene sequences (Li, Wu, and Luo 1984); pseud 2 – data for the psi-eta-globin pseudogenes of primates (Yang 1994); pseud m and pseud h – data for LDH-A pseudogenes of mouse and human respectively (Fukasawa et al. 1986); mtdros 4d and mtdros 3p – data for cytochrome b and NADH dehydrogenase subunit 1 genes of Drosophila mtDNA for four-fold degenerate sites and the third codon positions (Tamura 1992); mtDNA 1, 2p – data for the first and the second codon positions of vertebrate mitochondrial genes (Zhang 1999) Notes: The last column represents data for substitutions in mitochondrial sequences under strong selection pressure; p_mut – parameter for τ counting equals 0,01. For more explanations see text.

ISSN: 2730-7182