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Table 1 Tables of substitutions, DNA composition in the equilibrium with the mutational pressure and half times of nucleotide substitutions.

From: High correlation between the turnover of nucleotides under mutational pressure and the DNA composition

Substitution BbTS real BbTS artificial pseud 1 pseud 2 pseud m pseud h mtdros 4d mtdros 3p mtDNA l, 2p
A>T 0,103 0,222 0,047 0,024 0,017 0,087 0,124 0,019 0,069
A>G 0,067 0,111 0,050 0,138 0,068 0,149 0,013 0,148 0,082
A>C 0,023 0,016 0,094 0,031 0,068 0,000 0,029 0,005 0,094
T>A 0,066 0,189 0,044 0,024 0,057 0,025 0,004 0,021 0,054
T>G 0,035 0,002 0,082 0,030 0,114 0,013 0,075 0,005 0,016
T>C 0,035 0,002 0,033 0,126 0,095 0,025 0,379 0,086 0,182
G>A 0,164 0,023 0,210 0,214 0,166 0,177 0,056 0,449 0,118
G>T 0,116 0,178 0,072 0,047 0,030 0,076 0,000 0,041 0,030
G>C 0,015 0,056 0,053 0,051 0,060 0,050 0,000 0,000 0,031
C>A 0,070 0,186 0,065 0,052 0,076 0,052 0,288 0,000 0,087
C>T 0,261 0,010 0,210 0,211 0,172 0,312 0,000 0,227 0,216
C>G 0,047 0,004 0,042 0,054 0,076 0,035 0,124 0,000 0,020
DNA composition
A 30,8 30,8 31,3 30,8 41,0 17,0 27,4 29,8 24,7
T 48,5 48,5 37,2 30,8 17,1 65,6 50,1 43,6 31,5
G 13,8 13,8 15,8 19,9 23,9 11,7 8,3 9,4 17,2
C 6,9 6,9 15,8 18,5 18,1 5,6 14,3 17,2 26,6
Half time of substitution
τA 361 199 364 360 450 294 412 404 283
τT 513 359 437 385 262 1103 637 622 274
τG 236 269 207 223 270 229 159 141 388
τC 183 346 219 219 214 174 240 306 214
Correlation coeff. 0,999 0,072 0,998 0,991 0,967 0,998 0,997 0,988 -0,764
  1. Explanations: BbTS real – the table of substitutions in the B. burgdorferi genome on the leading strand estimated as described in the Method section; BbTS artificial – one of the possible tables which produce the DNA asymmetry and composition like BbTS real; pseud 1 – data for mammal pseudogene sequences (Li, Wu, and Luo 1984); pseud 2 – data for the psi-eta-globin pseudogenes of primates (Yang 1994); pseud m and pseud h – data for LDH-A pseudogenes of mouse and human respectively (Fukasawa et al. 1986); mtdros 4d and mtdros 3p – data for cytochrome b and NADH dehydrogenase subunit 1 genes of Drosophila mtDNA for four-fold degenerate sites and the third codon positions (Tamura 1992); mtDNA 1, 2p – data for the first and the second codon positions of vertebrate mitochondrial genes (Zhang 1999) Notes: The last column represents data for substitutions in mitochondrial sequences under strong selection pressure; pmut – parameter for τ counting equals 0,01. For more explanations see text.